Mice of the WldS strain have normal axoplasmictransport but show an abnormally slow rate of axon and myelin degeneration.
2
In contrast, there was significantly less SP IR observed from nerve of adrenal-transplanted rats, suggesting a diminution of anterograde axoplasmictransport by adrenal transplants.
Ús de axonal transport en anglès
1
Collectively, the data provide a biological basis for Aβ-induced axonaltransport deficits.
2
Recent studies suggest that axonaltransport of mitochondria along microtubules is disrupted in ALS.
3
Thus, synapsin I does not appear to inhibit the fast axonaltransport mechanism itself.
4
In addition, beta-amyloid precursor protein staining indicated impaired axonaltransport.
5
This enzyme deacetylates microtubules and plays a crucial role in the regulation of axonaltransport.
6
Excess of non-functional GSK-3β did not affect axonaltransport.
7
We studied slow axonaltransport and morphometry of forelimb axons in wobbler mice and controls.
8
Kinesin is believed to generate force for the movement of organelles in anterograde axonaltransport.
9
Spheroids demonstrated increased immunoreactivity to amyloid precursor protein and neurofilament indicating probable impairment of axonaltransport.
10
Surprisingly, however, this combination suppressed rather than increased APP-induced axonaltransport defects in both Drosophila and mice.
11
In addition, we summarize the therapeutic approaches targeting the axonaltransport machinery in studies of neurodegenerative diseases.
12
Synaptic vesicles apparently retain the capacity for fast axonaltransport, even after they reach their intracellular destination.
13
We propose that the axonaltransport impairment may be a deleterious consequence of accumulated, toxic MAP8 protein.
14
Recent work indicates that in many neurodegenerative diseases long distance axonaltransport is perturbed, leading to axonal blockages.
15
Previous studies have provided compelling evidence that conventional kinesin is a major motor for anterograde fast axonaltransport.
16
Although previous studies have demonstrated Aβ-induced transport blockade, early effects of low-n soluble Aβ-oligomers on axonaltransport remain unclear.